Age

≤ 70 years

> 70 years

Tumor Status

Primary

Recurrent

Number of Tumors

Single

Multiple

Maximum Tumor Diameter

< 3 cm

≥ 3 cm

Stage

Ta

T1

Concomitant CIS

No

Yes

Select Classification System

Either the WHO 1973, the WHO 2004/2016, or both grading classification systems can be selected.

WHO Grade 2004/2016

LMP-LG

HG

WHO Grade 1973

G1

G2

G3

The form is incomplete, please review it to unlock the "Calculate" button bellow.

Results

Probability of progression after TURBT without induction or maintenance BCG
	Based on WHO 2004/2016	Based on WHO 1973

at 1 year
at 5 years
at 10 years
Probability of Progression and 95% Confidence Interval

EAU NMIBC Risk Calculator
    
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    Based on WHO 2004/2016: {{who2004_result}}
    
    At 1 year: {{who2004_1y}}
    At 5 years: {{who2004_5y}}
    At 10 years: {{who2004_10y}}
    (Probability of progression and 95% confidence interval)
    
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    {{who1973
    Based on WHO 1973: {{who1973_result}}
    
    At 1 year: {{who1973_1y}}
    At 5 years: {{who1973_5y}}
    At 10 years: {{who1973_10y}}
    (Probability of progression and 95% confidence interval)

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    To know more, you can download the EAU NMIBC Risk Calculator from the Apple App Store and from the Google Play Store, or try it online at https://nmibc.net/
    
    iOS: https://apps.apple.com/us/app/eau-nmibc-risk-calculator/id1578482687
    Android: https://play.google.com/store/apps/details?id=net.ydeal.nmibc

Disclaimer
    
    This app estimates the probability of a Non–muscle Invasive Bladder Cancer (NMIBC) patient’s progression to MIBC after trans-urethral resection of bladder tumours (TURBT) and calculates their updated European Association of Urology (EAU) Prognostic Factor Risk Group. It Incorporates both the WHO 2004/2016 and WHO 1973 Grading Classification Systems and is based on the following publication:
    
    Sylvester RJ, et al. European Association of Urology (EAU) Prognostic Factor Risk Groups for Non–muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel. Eur Urol (2021), https://doi.org/10.1016/j.eururo.2020.12.033

It is a tool that can be used to help inform treatment decisions, but it does not provide professional advice and it can never replace clinical expertise. Treatment decisions for individual patients should take into account not only clinical expertise, but also patient personal values and their preferences.

This calculator has been developed by Ydeal for the EAU. Its developers and its distributors assume no responsibility for the accuracy of the results that are provided or for possible flaws in the system. Nor are they liable for special, direct, indirect or consequential damages, charges, claims, costs, demands, losses, fees or expenses of any nature or kind arising from use of the system.

Comments, suggestions and any errors that are found should be sent to info@nmibc.net

By using the system, the User agrees to these conditions and to abide by international copyright laws and all other applicable laws involving copyright.

Clinical composition of the new EAU NMIBC prognostic factor risk groups based on WHO 2004/2016 or WHO 1973 grading classification systems

Low Risk

A primary, single, Ta LG/G1 tumor ≤ 3 cm in diameter without CIS in a patient ≤ 70 years

A primary LG/G1 tumor with at most ONE of the following additional clinical risk factors:

Age > 70
Multiple tumors
Tumor diameter ≥ 3 cm
Stage T1

Intermediate Risk

Patients without CIS who are not included in either the low, high or very high-risk groups

High Risk

All T1 HG/G3 without CIS, EXCEPT those included in the very high-risk group

All CIS patients, EXCEPT those included in the very high-risk group

Stage, grade with additional clinical risk factors*:

Ta LG/G2 or T1 G1, no CIS with all 3 risk factors
Ta HG/G3 or T1 LG, no CIS with at least 2 risk factors
T1 G2 no CIS with at least 1 risk factor

Very High Risk

Stage, grade with additional clinical risk factors*:

Ta HG/G3 and CIS with all 3 risk factors
T1 G2 and CIS with at least 2 risk factors
T1 HG/G3 and CIS with at least 1 risk factor
T1 HG/G3 no CIS with all 3 risk factors

Tumors with:

CIS in the prostatic urethra
Lymphovascular invasion
Variant histology

* The additional clinical risk factors are age > 70, multiple tumors, and tumor diameter ≥ 3 cm

Risk Groups Table

Risk Group	Probability of Progression and 95% Confidence Interval
Risk Group	1 Year	5 Years	10 Years
New Risk Groups with WHO 2004/2016
Low	0.06%, 0.01%-0.43%	0.93%, 0.49%-1.7%	3.7%, 2.3%-5.9%
Inter	1.0%, 0.50%-2.0%	4.9%, 3.4%-7.0%	8.5%, 5.6%-13%
High	3.5%, 2.4%-5.2%	9.6%, 7.4%-12%	14%, 11%-18%
Very High	16%, 10%-26%	40%, 29%-54%	53%, 36%-73%
New Risk Groups with WHO 1973
Low	0.12%, 0.02%-0.82%	0.57%, 0.21%-1.5%	3.0%, 1.5%-6.3%
Inter	0.65%, 0.36%-1.2%	3.6%, 2.7%-4.9%	7.4%, 5.5%-10%
High	3.8%, 2.6%-5.7%	11%, 8.1%-14%	14%, 10%-19%
Very High	20%, 12%-32%	44%, 30%-61%	59%, 39%-79%

About

This app estimates the probability of a Non–muscle Invasive Bladder Cancer (NMIBC) patient’s progression to MIBC after trans-urethral resection of bladder tumours (TURBT) and calculates their updated European Association of Urology (EAU) Prognostic Factor Risk Group. It Incorporates both the WHO 2004/2016 and WHO 1973 Grading Classification Systems and is based on the following publication:

Sylvester RJ, et al. European Association of Urology (EAU) Prognostic Factor Risk Groups for Non–muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel. Eur Urol (2021), https://doi.org/10.1016/j.eururo.2020.12.033